Seton Catholic Central was built in 1962 at 70 Seminary Ave in Binghamton, NY and opened as Catholic Central High School in 1963. When the school opened as Seton Catholic Central High School in 1976, it housed students from both Catholic Central High School in Binghamton, NY and Seton Catholic High School in Endicott, NY. The schools had to merge because of declining enrollments and a deficit. The Sisters of Charity, who staffed Seton, and the Sisters of St. Joseph, who manned Catholic Central, were moved to the new school to be the main part of the faculty with Reverend VanAmburgh as the principal. The tuition at the time of the merger was $500 per student (it had increased $50 more than the tuition at the two high schools), with a maximum of $950 per family.
The class of 1977 was the first graduating class from Seton Catholic Central and had 281 members in it. Classes included math, science, English, foreign language (including Spanish), physical education, social studies, and business. Popular activities for students included chorus, newspaper, ski club, Marian Association, key club, mission club, pep club, bowling, and basketball.
The building has two floors and a basement with 39 classrooms, including the band room, chorus room, computer lab, science labs and art room. The gymnasium has been used for various sporting events, including basketball, musicals and plays (featured on the stage), graduations, masses, assemblies, and other events. The building also has a chapel near the gym that is used for daily masses and is also used by religion classes during the school day. Within the building there is also a library with computers that is used for studying, the Saintly Grounds afterschool café, and a main office.
In 2011, Seton Catholic Central High School became Seton Catholic Central when it opened its doors to students in 7th and 8th grades. Today Seton Catholic Central has students in grades 7- 12 and has approximately 355 students, with Mr. Richard Bucci as the principal. The school offers many class options for all learning levels, as well as many sports and activities for all students. Students from all over the Binghamton area attend the school, as well as international students from places such as Germany, Italy and Asia.